Postdoc (m/f/d) in the field of Leukemia and Chromatin Biology

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Postdoc (m/f/d) in the field of Leukemia and Chromatin Biology

Location:
Vienna

Research group:
Davide Seruggia Group

Working hours:
Full-time

We are looking for post-doctoral researchers (wet-lab and computational) to join our research group. These positions offer a unique opportunity to answer important questions in the fields of chromatin biology, hematopoiesis and leukemia, and to have a direct impact on the development of new cancer therapies.

Our group (www.seruggialab.com) is interested in gene regulation in the context of pediatric cancer, and focuses on the study of non-coding regulatory sequences (enhancers, boundary elements) as well as protein complexes involved in the control of gene expression (transcription factors, co-activators). We use genome editing (CRISPR screenings, CRISPRi/a, dense mutagenesis), chromatin profiling (ChIP-seq, CUT and RUN, ATAC-seq), proteomics, mouse models and computational approaches to identify and characterize cancer vulnerabilities. The project is funded by a Starting Grant from the ERC and will investigate how mutations at enhancers drive leukemia development and will elucidate the effect of sequence variation at transcription factor binding sites. Our group is also affiliated with the CeMM, where we have access to top-notch facilities for next-generation sequencing, proteomics and metabolomics as well as structured PhD and postdoctoral programs.

Relevant publications: Seruggia et al. Molecular Cell 2019; Sher, Hossain, Seruggia et al. Nature Genetics 2019; Seruggia et al. Scientific Reports 2020; Debruyne et al. Nature 2019; Seruggia et al Nucleic Acids Research 2015.

As a postdoc, you will

  • Work on competitive, exciting projects aimed to dissect mechanisms of gene expression in cancer
  • Collaborate with scientists at the CCRI, at institutions in Vienna and with international partners
  • Contribute to the supervision of junior group members, write manuscripts and grant applications

Your Profile

  • PhD in a relevant subject (molecular biology, cancer, hematopoiesis, computational biology, statistics)
  • Proven track record (at least one first-author publication in a reputable journal)
  • Background in molecular biology, genomics and hematopoiesis
  • Prior experience in flow cytometry and mouse models (wet-lab applicants)
  • Experience with processing of -omics data, ability to generate ad hoc tools and pipelines (computational applicants)
  • Excellent verbal and written communication skills in English (German not required)
  • Good team player, enthusiasm, commitment, and creativity

Our Offer

  • A meaningful, inspiring, and international environment
  • An outstanding working atmosphere in a young, strong team with excellent research and development opportunities
  • Access to state-of-the-art infrastructure in a well-funded lab and institution
  • Great location in the center of Vienna, a capital of biomedical research in Europe with excellent quality of life
  • A fair and attractive salary package according to the Austrian Science Fund FWF (https://www.fwf.ac.at/en/research-funding/personnel-costs/)

Who we are

The St. Anna Children's Cancer Research Institute (CCRI), located in the center of Vienna, the world's most livable city and one of Europe's most important places for biomedical research and life sciences, is an international and multidisciplinary competence center striving to improve treatment of children and adolescents with cancer by connecting translational and clinical research with open-minded exploration of basic disease mechanisms. Through close cooperation between clinic and research, the CCRI provides an ideal environment for cutting-edge research and its translation into clinical practice. To achieve our ultimate goal of advancing the well-being of patients, the CCRI constantly pushes scientific boundaries and strongly promotes close collaboration and exchange with external institutions like the Medical University of Vienna, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), and the Institute of Molecular Pathology (IMP).

The CCRI is an equal opportunity employer. We value diversity and are committed to providing a work environment of mutual respect to everyone without regard to race, color, religion, national origin, age, gender identity or expression, disability, or any other characteristic protected by applicable laws, regulations and ordinances.

Find more information here: https://science.ccri.at/ or https://kinderkrebsforschung.at/

Your application

Please send your application via email to Davide Seruggia, application@ccri.at.
Applications should contain your Curriculum Vitae, a cover letter, list of publications (please mark / explain your three top contributions), and the contact details of three references.

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